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Articles Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 GBD 2017 Diet Collaborators* Lancet 2019; 393: 1958–72 Published Online April 3, 2019 http://dx.doi.org/10.1016/ S0140-6736(19)30041-8 See Comment page 1916 *Collaborators listed at the end of the paper Correspondence to: Prof Christopher J L Murray, Institute for Health Metrics Evaluation, University of Washington, Seattle, WA 98121, USA cjlm@uw.edu Summary Background Suboptimal diet is an important preventable risk factor for non-communicable diseases (NCDs); however, its impact on the burden of NCDs has not been systematically evaluated. This study aimed to evaluate the consumption of major foods and nutrients across 195 countries and to quantify the impact of their suboptimal intake on NCD mortality and morbidity. Methods By use of a comparative risk assessment approach, we estimated the proportion of disease-specific burden attributable to each dietary risk factor (also referred to as population attributable fraction) among adults aged 25 years or older. The main inputs to this analysis included the intake of each dietary factor, the effect size of the dietary factor on disease endpoint, and the level of intake associated with the lowest risk of mortality. Then, by use of disease- specific population attributable fractions, mortality, and disability-adjusted life-years (DALYs), we calculated the number of deaths and DALYs attributable to diet for each disease outcome. Findings In 2017, 11 million (95% uncertainty interval [UI] 10–12) deaths and 255 million (234–274) DALYs were attributable to dietary risk factors. High intake of sodium (3 million [1–5] deaths and 70 million [34–118] DALYs), low intake of whole grains (3 million [2–4] deaths and 82 million [59–109] DALYs), and low intake of fruits (2 million [1–4] deaths and 65 million [41–92] DALYs) were the leading dietary risk factors for deaths and DALYs globally and in many countries. Dietary data were from mixed sources and were not available for all countries, increasing the statistical uncertainty of our estimates. Interpretation This study provides a comprehensive picture of the potential impact of suboptimal diet on NCD mortality and morbidity, highlighting the need for improving diet across nations. Our findings will inform implementation of evidence-based dietary interventions and provide a platform for evaluation of their impact on human health annually. Funding Bill & Melinda Gates Foundation. Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Introduction The relationship between dietary habits and chronic non- communicable diseases (NCDs) has been extensively investigated. 1–5 Long-term randomised trials with NCD endpoints have not been feasible for most dietary factors, but synthesis of other lines of epidemiological evidence, including long-term prospective observational studies and short-term trials of intermediate outcomes, have provided supporting evidence for potential causal relationships between specific dietary factors (eg, fruits, vegetables, processed meat, and trans fat intake) and NCDs (ischaemic heart disease, diabetes, and colorectal cancer). 2–7 These findings have been widely used to inform national and international dietary guidelines aimed at preventing NCDs. 8,9 However, because of the complexities of characterising dietary consumption across different nations, assessment of the health effects of suboptimal diet at the population level has not been possible. In the past decade, efforts have been made to quantify the burden of disease attributable to specific dietary factors. 10–19 These efforts, although useful, had several important limitations, including insufficient geograph­ ically representative data on dietary consumption, inaccurate characterisation of population distribution of dietary intake, insufficient accounting for biases of dif­ ferent sources of dietary assessment, standardisation of the intake to 2000 kcal per day, and insufficient accounting for within-person variation of intake of dietary factors. To address these limitations, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we systematically collected geographically representative dietary data from multiple sources, characterised the population distribution of intake for 15 foods and nutrients among adults aged 25 years or older across 195 countries, estimated the effect of each individual dietary factor on NCD mortality, and quantif­ied the overall impact of poor dietary habits on NCD mortality. We also evaluated the relationship between diet and socioeconomic development, and assessed the trends in disease burden of diet over time. This analysis supersedes all previous results from 1958 www.thelancet.com Vol 393 May 11, 2019

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